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KMID : 0604220060130010001
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Korean Journal Investigative Dermatology
2006 Volume.13 No. 1 p.1 ~ p.4
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Characteristics and Separation of Epidermal Stem Cells
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Park Kyoung-Chan
Youn Sang-Woong
Cho Hyun-Joo
Kim Dong-Seok
Choi Hye-Ryung
Kwon Sun-Bang
Na Jung-Im
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Abstract
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Stem cells are vital for the homeostasis of self-renewing tissues and their manipulation may have wide applications, including gene therapy, would repair, and tissue transplantation. Renewal of epidermis is achieved by an ordered replication of stem cells and transit amplifying cells followed by terminal differentiation. Although the existence of epithelial stem cells in the skin has been known for some decades from kinetic studies performed in vivo, attempts to isolate these cells have been made recently facilitated by the availability of antibodies that direct cell surface markers on epidermal cells. However, isolation of these cells are not sufficient yet for further biologic study because of limited yield and need of expensive equipment. In this paper, markers of epithelial stem cells and purification methods will be discussed in terms of stem cell characteristics, location, differentiation abilities and clinical implications.
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KEYWORD
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Stem cells, Epidermis, Isolation
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